Epidemiology of paediatric visceral leishmaniasis in Hebron district, Palestine.
Trans R Soc Trop Med Hyg
; 103(7): 731-6, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19022464
ABSTRACT
Seventy-six cases of visceral leishmaniasis (VL) were reported from the Hebron district of the West Bank, Palestine between 1993 and 2007. All cases were in children less than 9 years old (median age 2 years). The average number of cases was 5.06/year and the average annual incidence was 3.02/100000 children. Ribosomal internal transcribed spacer 1 (ITS1) PCR-RFLP was performed using DNA extracted from two cultures and 36 archived Giemsa-stained slides from VL patients. Leishmania infantum was revealed as the causative agent of VL in the focus. Isoenzyme analysis identified two isolates as zymodeme MON-1. A serological survey of 455 children screened for serum anti-Leishmania antibodies revealed 8.4% seropositivity. Seropositivity was highest for children in households of previous VL cases [odds ratio (OR) 7.5; 95% CI 3.17-17.61; P<0.001] and among people who had domestic dogs and/or other animals (OR 2.4; 95% CI 1.19-4.68; P=0.017). No difference was seen between males and females (P=0.073). A preliminary survey of sand fly distribution showed the abundance of two putative vector species Phlebotomus syriacus (45%) and Ph. tobbi (10%). The focus of VL in Hebron district was shown to follow the epidemiological pattern of paediatric disease characteristic of the Mediterranean region.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zoonoses
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Leishmania infantum
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Leishmaniose Visceral
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
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Incidence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Animals
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha