Restoration of high immunoglobulin gene expression in chronic lymphoid leukemia: a possible application for gene therapy.
Cell Immunol
; 135(2): 326-34, 1991 Jul.
Article
em En
| MEDLINE
| ID: mdl-1903674
ABSTRACT
In this study, using interleukin-2 and gamma interferon, we first induced the differentiation into plasma cells of primary chronic lymphoid leukemic B cells from patients whose T cells failed to produce interleukin-2. We next demonstrated that these malignant primary B lymphocytes (i.e., lymphocytes which have not been subjected to any procedure aiming at their immortalization or their transformation into cell lines) functionally expressed transfected genes under the control of exogeneous Ig promoters and enhancers during their terminal differentiation into plasma cells. We discussed the possibility of applying this approach to gene therapy to correct this type of lymphocytic leukemia in man.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genes de Imunoglobulinas
/
Terapia Genética
/
Leucemia Linfocítica Crônica de Células B
Limite:
Humans
Idioma:
En
Revista:
Cell Immunol
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
França