Characterization of neutralizing epitopes of varicella-zoster virus glycoprotein H.
J Virol
; 83(4): 2020-4, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19073736
ABSTRACT
Varicella-zoster virus (VZV) glycoprotein H (gH) is the major neutralization target of VZV, and its neutralizing epitope is conformational. Ten neutralizing human monoclonal antibodies to gH were used to map the epitopes by immunohistochemical analysis and were categorized into seven epitope groups. The combinational neutralization efficacy of two epitope groups was not synergistic. Each epitope was partially or completely resistant to concanavalin A blocking of the glycomoiety of gH, and their antibodies inhibited the cell-to-cell spread of infection. The neutralization epitope comprised at least seven independent protein portions of gH that served as the target to inhibit cell-to-cell spread.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
/
Glicoproteínas de Membrana
/
Herpesvirus Humano 3
/
Mapeamento de Epitopos
/
Epitopos
Limite:
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Japão