[Tongxinluo improves vascular endothelial function in patients with type 2 diabetes].
Zhonghua Xin Xue Guan Bing Za Zhi
; 36(4): 337-40, 2008 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-19100012
ABSTRACT
OBJECTIVE:
To investigate the effects of Tongxinluo on vascular endothelial function in patients with type 2 diabetes.METHODS:
A total of 80 patients with type 2 diabetes were recruited and divided into two groups Tongxinluo therapy group (n = 40) and conventional therapy group (n = 40). Plasma levels of NO, ET, 6-keto-PGF1alpha and TXB2 and diastolic functions of humeral arteries (measured by high-resolution ultrasound) were measured at baseline and 4 weeks later.RESULTS:
The flow-mediated dilation was significantly increased from (8.19 +/- 0.71)% to (12.47 +/- 0.98)% (P < 0.05) in Tongxinluo therapy group after 4 weeks therapy compare to baseline level. Their plasma NO was significantly increased [(47.65 +/- 4.38) pg/ml to (52.91 +/- 4.83) pg/ml, P < 0.001] and plasma ET significantly reduced [(31.23 +/- 2.46) pg/ml to (24.34 +/- 2.46) pg/ml, P < 0.001] post 4 week Tongxinluo therapy. Parameters remained unchanged in the placebo group (P > 0.05) at baseline and 4 weeks later. Non-flow-mediated dilation was unaffected by Tongxinluo therapy.CONCLUSIONS:
Tongxinluo improved the vascular endothelial dependent diastolic function in patients with type 2 diabetes by regulating the balance of plasma NO/ET.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Endotélio Vascular
/
Diabetes Mellitus Tipo 2
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Xin Xue Guan Bing Za Zhi
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
China