Prenatal hyperhomocysteinemia as a model of oxidative stress of the brain.
Bull Exp Biol Med
; 146(1): 33-5, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-19145343
ABSTRACT
We found that methionine added to the ration of pregnant rats (1 g/kg body weight) induced sustained hyperhomocysteinemia and led to the formation of sustained oxidative stress in the brain of their progeny. Newborn animals were characterized by lower body weight, SOD deficiency in the brain, increased neuronal death, and desensitization of NMDA receptors. These factors are associated with impaired cognitive capacity in the Morris test.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Estresse Oxidativo
/
Hiper-Homocisteinemia
/
Feto
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Federação Russa