Inhibition of phorbol ester-induced cell activation in microgravity.
Exp Cell Res
; 197(1): 82-6, 1991 Nov.
Article
em En
| MEDLINE
| ID: mdl-1915666
ABSTRACT
T lymphocytes and monocytes were exposed to microgravity and activated to produce interleukin 2 and interleukin 1, respectively. When Jurkat T cells were triggered with monoclonal antibodies directed against the CD3/T cell receptor complex in the presence of THP-1 monocytes used as accessory cells, cell-to-cell contacts took place in microgravity leading to normal production of interleukin 2 and interleukin 1, as compared to ground controls. In contrast, when cells were individually stimulated by soluble substances including a protein kinase C activating phorbol ester, the production of interleukin 1 and interleukin 2 was dramatically inhibited during microgravity exposure. This result indicates that microgravity may affect the cellular target of phorbol ester.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ausência de Peso
/
Ativação Linfocitária
/
Monócitos
/
Linfócitos T
Idioma:
En
Revista:
Exp Cell Res
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
França