High efficacy of bismuth subcitrate for Helicobacter pylori eradication in pangastritis.
Dig Liver Dis
; 41(8): 555-8, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19179127
ABSTRACT
BACKGROUND:
The influence of gastritis patterns in Helicobacter pylori eradication rates has been poorly investigated.AIMS:
To compare the efficacy of bismuth or proton pump inhibitors triple therapy for H. pylori eradication in pangastritis. PATIENTS ANDMETHODS:
One hundred and eight patients with pangastritis were assigned to either lansoprazole 30 mg once a day (n=54) or bismuth 240 mg bis in die (n=54) for 14 days combined, for the first week, with amoxicillin 1g plus metronidazole 250 mg tris in die. Eradication was confirmed by (13)C-urea breath test.RESULTS:
With bismuth, successful eradication was observed in 75.9% (41/54) in the intention-to-treat analysis and 78.8% (41/52) in the per-protocol analysis. With lansoprazole, the eradication rates were respectively 46.3% (25/54) and 51.0% (25/49). Bismuth had a significant higher efficacy according to both intention-to-treat analysis (p=0.0029) and per-protocol analysis (p=0.0038) with OR of 3.66 (95% CI 1.61-8.32) and 3.58 (95% CI 1.50-8.54) respectively. At regression analysis, the only independent variable affecting eradication was the type of regimen (p=0.026) with an OR of 3.31 (95% CI 1.16-9.44).CONCLUSIONS:
In pangastritis patients, bismuth is more effective than PPI in first-line eradication. For improving the overall eradication rates, an evaluation of gastritis extent might need to be considered.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Helicobacter pylori
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Infecções por Helicobacter
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Gastrite
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Anti-Infecciosos
/
Antiulcerosos
Tipo de estudo:
Clinical_trials
/
Guideline
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Dig Liver Dis
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Itália