Microbial transformation of bufotalin by Alternaria alternata AS 3.4578.

Xin, Xiu-Lan; Zhan, Li-Bin; Li, Feng-Yun; Ma, Xiao-Chi; Liu, Ke-Xin; Han, Jian; Guo, De-An

Xin, Xiu-Lan; Zhan, Li-Bin; Li, Feng-Yun; Ma, Xiao-Chi; Liu, Ke-Xin; Han, Jian; Guo, De-An.

Afiliação

Xin XL; The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.

J Asian Nat Prod Res ; 11(1): 7-11, 2009.

Article em En | MEDLINE | ID: mdl-19180348

RESUMO

The microbial transformation of a cytotoxic bufadienolide, bufotalin (1), was carried out. Three transformed products from 1 by Alternaria alternata were isolated. Their structures were characterized as 3-keto-bufotalin (2), 12 beta-hydroxyl-bufotalin (3), and 3-keto-12 beta-hydroxyl-bufotalin (4) based on the extensive NMR studies. Among them, 3 and 4 were new compounds with strong in vitro cytotoxic activities against HeLa cells.

Assuntos

Alternaria/metabolismo; Antineoplásicos Fitogênicos/metabolismo; Bufanolídeos/metabolismo; Antineoplásicos Fitogênicos/química; Antineoplásicos Fitogênicos/farmacologia; Biotransformação; Bufanolídeos/química; Bufanolídeos/farmacologia; Ensaios de Seleção de Medicamentos Antitumorais; Células HeLa; Humanos; Estrutura Molecular; Ressonância Magnética Nuclear Biomolecular

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bufanolídeos / Alternaria / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2009 Tipo de documento: Article País de afiliação: China

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