Membranous nephropathy associated with IgG4-related systemic disease and without autoimmune pancreatitis.
Clin Nephrol
; 71(2): 173-8, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19203510
ABSTRACT
We describe an elderly man with membranous nephropathy and lymphoplasmacytic infiltration into the renal interstitium who presented with a high serum IgG4 concentration and no organ involvement in the pancreatobiliary system. Although the patient had hypocomplementemia and was positive for antinuclear antibodies, he was negative for antibodies against Sm, SS-A, SS-B and RNP, and his anti-DNA antibody titer was not elevated. Immunohistochemistry demonstrated that the infiltrated plasma cells in the renal interstitium and glomerular capillary walls were strongly positive for IgG4. Electron microscopy showed electron-dense deposits on the glomerular basement membranes and tubular basement membranes. The present case suggests that membranous nephropathy, like tubulo-interstitial nephritis, is one of the renal features of IgG4-related systemic disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Glomerulonefrite Membranosa
Tipo de estudo:
Risk_factors_studies
Limite:
Aged80
/
Humans
/
Male
Idioma:
En
Revista:
Clin Nephrol
Ano de publicação:
2009
Tipo de documento:
Article