Calciotropic hormones, insulin resistance, and the polycystic ovary syndrome.
Fertil Steril
; 93(4): 1208-14, 2010 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-19230880
ABSTRACT
OBJECTIVE:
To investigate whether abnormalities in serum concentrations of 1,25-dihydroxyvitamin D [1,25(OH)(2)D], 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), calcium, and phosphorus were associated with risk of polycystic ovary syndrome (PCOS) and obesity. The possible correlations of the calciotropic hormones with insulin resistance were also examined.DESIGN:
Case-control study.SETTING:
Department of Genetics, Royan Institute. PATIENT(S) Eighty-five women with PCOS and 115 control women were recruited. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Serum levels of glucose, insulin, total calcium, phosphorus, PTH, 25(OH)D, and 1,25(OH)(2)D were measured in all 200 subjects. RESULT(S) The presence of PCOS had age- and body mass index (BMI)-independent positive effects on serum phosphorus, PTH, 25(OH)D, and insulin concentrations as well as on insulin resistance. Furthermore, overweight/obese (BMI > or =25 kg/m(2)) women with PCOS had significantly decreased levels of 1,25(OH)(2)D and glucose compared with normal-weight (BMI <25 kg/m(2)) women with PCOS. In women with PCOS, phosphorus was correlated negatively with insulin and insulin resistance and positively with 1,25(OH)(2) D. In addition, in normal-weight patients, PTH correlated positively with insulin and insulin resistance. CONCLUSION(S) It is possible that elevated levels of phosphorus and PTH in women with PCOS, at least in part, through their effects on insulin levels and insulin resistance, are involved in pathogenesis of the syndrome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio Paratireóideo
/
Fósforo
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Síndrome do Ovário Policístico
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Vitamina D
/
Resistência à Insulina
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Cálcio
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
/
Middle aged
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Irã