The relationship between slow coronary flow and angiotensin converting enzyme and ATIIR1 gene polymorphisms.
J Natl Med Assoc
; 101(1): 40-5, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19245071
ABSTRACT
OBJECTIVES:
Endothelial dysfunction in coronary arteries is the main pathogenetic mechanism in patients with slow coronary flow (SCF). Angiotensin converting enzyme (ACE) gene polymorphism has important effects on endothelial function. However, angiographic studies investigating the relation between the ACE and angiotensin II type 1 receptor (ATIIR1) insertion (I)/deletion (D) polymorphism and SCF is limited.METHODS:
Fifty-four patients with normal coronary arteries documented by coronary angiography with SCF in any coronary vessel, and 22 subjects with normal coronary arteries without SCF were included in this study. The ID (I/D), II, and DD genotypes were examined.RESULTS:
Frequency of DD genotype was found higher in SCF group (50% vs. 27%, respectively; p = .055). Frequency of D allele was significantly higher in the SCF group (p < .05). Presence of DD genotypes increased the possibility of SCF 5.25 times compared to absence of DD genotype (OR, 5.25; 95% CI, 1.30-21.38, p < .05). There was no significant correlation of ATIIR1 gene polymorphism between the 2 groups.CONCLUSIONS:
We demonstrated that DD genotype is a risk factor for SCF. Determination of ACE gene polymorphism in patients with SCF may be helpful in medical management and risk stratification.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Velocidade do Fluxo Sanguíneo
/
Peptidil Dipeptidase A
/
Circulação Coronária
/
Doença das Coronárias
/
Receptor Tipo 1 de Angiotensina
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Natl Med Assoc
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Turquia