Prevalence of autoimmune thyroiditis in children with celiac disease and effect of gluten withdrawal.
J Pediatr
; 155(1): 51-5, 55.e1, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19324373
ABSTRACT
OBJECTIVE:
To study the prevalence of autoimmune thyroiditis (AT) in Sardinian children with celiac disease (CD) and the effects of a gluten-free diet (GFD) on thyroid function. STUDYDESIGN:
Children with biopsy-proven CD (n = 324; femalemale 21; mean age, 6.6 years) followed from 1 to 15 years, were retrospectively evaluated for AT at onset of CD and during GFD. Serum thyroid peroxidase and thyroglobulin antibodies (AbTPO, AbTG), thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), and thyroid ultrasonography were considered. Age-matched Sardinian schoolchildren (n = 8040), previously evaluated for antithyroid antibodies and thyroid function, were used as controls.RESULTS:
Thirty-four patients with CD (10.5%) developed AT (femalemale 4,51; mean age, 10.5 years), 11 at onset of CD and 23 during GFD, with a higher prevalence than controls (P = 2.9(-13)). Twenty-eight patients were euthyroid and 6 hypothyroid. AbTPO and/or AbTG persisted elevated for 2 to 9 years despite the GFD in 9 of 11 patients with AT at onset of CD.CONCLUSIONS:
AT is strongly associated with CD in Sardinian children, has an age of onset of 10.5 years, and appears to be gluten-independent. In children with CD with AT, the femalemale bias reported in adult AT is present before puberty.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tireoidite Autoimune
/
Doença Celíaca
/
Dieta Livre de Glúten
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Pediatr
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Itália