[Expression and role of augmenter of liver regeneration in patients with hepatic failure].
Zhonghua Gan Zang Bing Za Zhi
; 17(3): 217-20, 2009 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-19335987
ABSTRACT
OBJECTIVE:
To investigate the expression and role of augmenter of liver regeneration (ALR) in hepatic failure.METHODS:
ALR polyclonal antibody was prepared and purified. Serum ALR in patients with hepatic failure, chronic hepatitis B and healthy persons were quantified by ELISA, ALR mRNA in hepatic tissues were quantified by real-time PCR.RESULTS:
Different serum ALR levels foreshowed different outcomes for hepatic failure patients The liver function was restored in 6 patients with higher ALR level [(1613.5+/-369.6) pmol/ml], and the liver function was deteriorated in 12 patients with lower ALR level [(462.3+/-235.8) pmol/ml]. ALR level in patients with chronic hepatitis B [(969.2+/-332.5) pmol/ml] was similar to that in healthy persons [(806.9+/-240.8) pmol/ml]. ALR mRNA level in hepatic failure patients receiving OLT (103.45 copies/microl) was lower than that in chronic hepatitis B patients (104.37 copies/microl) and healthy persons (104.31 copies/microl), ALR mRNA level in chronic hepatitis B and healthy persons was similar.CONCLUSION:
These findings suggest serum ALR level reflected ALR mRNA level in liver and is helpful in estimating the survival time of patients with hepatic failure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Falência Hepática Aguda
/
Hepatite B Crônica
/
Fígado
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
Idioma:
Zh
Revista:
Zhonghua Gan Zang Bing Za Zhi
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China