Distinct spatiotemporal pattern of CNS lesions revealed by USPIO-enhanced MRI in MOG-induced EAE rats implicates the involvement of spino-olivocerebellar pathways.
J Neuroimmunol
; 211(1-2): 49-55, 2009 Jun 25.
Article
em En
| MEDLINE
| ID: mdl-19346009
ABSTRACT
USPIO-enhanced MRI allows non-invasive visualization of mononuclear cell infiltration into CNS lesions in MS and EAE. Herein, we show a distinct spatiotemporal pattern of CNS lesions that reveals the involvement of spino-olivocerebellar pathways in MOG-induced EAE rats using USPIO-enhanced MRI. Specifically, lesions of the inferior olives were observed primarily in the acute phase whereas lesions of cerebellum or spinal cord/brainstem were observed during the relapse phase. Further, behavioral deficits observed from these animals are consistent with the functional role of spino-olivocerebellar pathways in coordination and movement. Collectively, our results provide new insights into the pathophysiology of this animal model of MS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
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Encéfalo
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Imageamento por Ressonância Magnética
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Encefalomielite Autoimune Experimental
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Vias Neurais
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos