Cryptococcus gattii meningoencephalitis in an immunocompetent person 13 months after exposure.
Infection
; 37(4): 370-3, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19390780
ABSTRACT
A 53-year old immunocompetent Swiss female is described who developed severe meningoencephalitis due to infection with Cryptococcus gattii 13 months following exposure on Vancouver Island, Canada. Diagnosis was based on cerebrospinal fluid (CSF) examination, i.e., positive India-ink staining, positive latex particle agglutination, and positive culture. Species identification was performed by growth on L-canavanine-glycine-bromthymol blue medium and by sequencing of the intergenic and internal transcribed spacer regions of the rRNA genes. After initial therapy with fluconazole by which the patient did not improve, therapy was changed to amphotericin B and flucytosine and later to high-dose fluconazole and amphotericin B. Despite long-term treatment and external drainage of the CSF, the patient's condition improved only slowly. The patient was discharged after 132 days of hospitalization.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Criptococose
/
Cryptococcus
/
Meningoencefalite
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Infection
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Suíça