Hypermethioninemia provokes oxidative damage and histological changes in liver of rats.
Biochimie
; 91(8): 961-8, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19426780
In the present study we evaluated the effect of chronic methionine administration on oxidative stress and biochemical parameters in liver and serum of rats, respectively. We also performed histological analysis in liver. Results showed that hypermethioninemia increased chemiluminescence, carbonyl content and glutathione peroxidase activity, decreased total antioxidant potential, as well as altered catalase activity. Hypermethioninemia increased synthesis and concentration of glycogen, besides histological studies showed morphological alterations and reduction in the glycogen/glycoprotein content in liver. Serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and glucose were increased in hypermethioninemic rats. These findings suggest that oxidative damage and histological changes caused by methionine may be related to the hepatic injury observed in hypermethioninemia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
/
Fígado
/
Metionina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochimie
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil