Expression and clinical significance of latent membrane protein-1, matrix metalloproteinase-1 and Ets-1 transcription factor in tunisian nasopharyngeal carcinoma patients.
Arch Med Res
; 40(3): 196-203, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19427971
ABSTRACT
BACKGROUND AND AIMS:
A prominent clinical feature of nasopharyngeal carcinoma (NPC) is its ability to easily invade local tissues and metastasize. In this field, latent membrane protein-1 (LMP-1), which is the principal Epstein-Barr virus-encoded oncoprotein, induces a set of factors that mediates angiogenesis and invasion. Matrix metalloproteinase-1 (MMP-1) and Ets-1 transcription factor are two other major factors that play crucial roles in tumor progression and may thus contribute to invasiveness of NPC cells. The aim of this study was to investigate the prognostic relevance of LMP-1 and its relationship with MMP-1 and Ets-1 expression in NPC biopsies.METHODS:
The expressions of LMP-1, MMP-1 and Ets-1 were immunohistochemically examined in 39 undifferentiated NPC specimens from Tunisian patients and the correlation between these proteins and clinicopathological parameters of the disease was statistically determined.RESULTS:
A significant association of LMP-1 expression with high T categories, as well as with the young age onset of NPC, has been found (p = 0.003). The expression of MMP-1 correlated with lymph node metastasis (p = 0.035), whereas a significant association between Ets-1 and high T categories, as well as distant metastasis, has been retrieved (p = 0.008; p = 0.047, respectively). In addition, the expression of LMP-1 showed a significant correlation with the expression of MMP-1 (p = 0.02).CONCLUSIONS:
The results of the current study suggest that LMP-1 may contribute to invasion and metastasis of undifferentiated NPCs through the induction of MMP-1.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma
/
Biomarcadores Tumorais
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Proteínas da Matriz Viral
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Neoplasias Nasofaríngeas
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Metaloproteinase 1 da Matriz
/
Proteína Proto-Oncogênica c-ets-1
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Arch Med Res
Assunto da revista:
MEDICINA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Tunísia