Are B cells a potential target for therapeutic intervention in the classical T cell-mediated autoimmune disease type 1 diabetes?
Inflamm Allergy Drug Targets
; 8(2): 130-8, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19530995
ABSTRACT
Incidence of autoimmune diseases is rising rapidly in the developed world and treatment of such diseases will be a major burden on Government health resources of the future. Whether systemic or organ-specific, immune cell destruction of the target tissue normally requires co-operative interaction of a many distinct immune cells. Detailed knowledge of the cells and signal pathways involved in tissue destruction is paramount to the design of novel therapeutics. Several organ-specific autoimmune diseases e.g. multiple sclerosis, rheumatoid arthritis and type 1 diabetes have long been attributed to T cell-mediated destruction of the target tissue. However, recent reports from both murine models and man have suggested that B cells are principal players in these T cell-mediated diseases. In this review, we discuss the evidence that supports a link between B cells and the autoaggressive T cell response in type 1 diabetes and how accumulating evidence suggests targeting B cells may offer a novel therapeutic strategy for this autoimmune disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoantígenos
/
Linfócitos B
/
Ilhotas Pancreáticas
/
Diabetes Mellitus Tipo 1
/
Imunoterapia
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Inflamm Allergy Drug Targets
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido