Antimicrobial, antiproliferative, cytotoxic, and tau inhibitory activity of rubellins and caeruleoramularin produced by the phytopathogenic fungus Ramularia collo-cygni.
Planta Med
; 75(14): 1523-5, 2009 Nov.
Article
em En
| MEDLINE
| ID: mdl-19565437
ABSTRACT
Photodynamically active anthraquinone derivatives produced by the phytopathogenic fungus Ramularia collo-cygni are known to cause a barley leaf-spot disease, but data about light-dependent and independent bioactivity have been sparse to date. We therefore conducted for the first time a broad bioactivity profiling of rubellins B, C, D, and E and caeruleoramularin. Antibacterial but not antiviral activity is reported with light-dependent increase. Furthermore, when tested without illumination, compounds exerted antiproliferative and cytotoxic activity in a series of human tumor cell lines. Inhibition of tau protein assembly was observed as well.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Bufanolídeos
/
Antraquinonas
/
Proteínas tau
/
Fungos Mitospóricos
/
Antibacterianos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Planta Med
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha