Long term follow-up and outcome of liver transplantation for alcoholic liver disease: a single center case-control study.
J Clin Gastroenterol
; 44(1): 52-7, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19581813
ABSTRACT
BACKGROUND:
Alcoholic liver cirrhosis (ALC) is a leading indication for orthotopic liver transplantation (OLT). GOALS To investigate the long-term outcome of OLT for ALC compared with patients transplanted for hepatitis C virus (HCV) infection. STUDY From 1987 to 2001, 49 OLT were performed for ALC and 173 for HCV. From these contemporary groups we matched 12 ALC patients (cases) to 98 HCV (controls). The following variables were analyzed survival, retransplantation, rejection, primary nonfunction, infections, de novo tumors, cardiovascular and neurologic complications, and alcoholic recurrence.RESULTS:
Actuarial survival rate at 9 years was comparable for cases and controls. Actuarial graft survival rate at 9 years was significantly higher in cases (78% vs. 60%; P=0.026). The retransplantation rate was higher in controls (21% vs. 4%; P=0.007). Post-OLT complications were not significantly different. The alcoholic recidivism rate was 28% without influence on patients or graft survival, whereas relapse of HCV caused the majority of death in controls (30%; P=0.042). At multivariate analysis retransplantation was the only predictor of patient survival (odds ratio 4.35; 95% confidence interval 2.16-8.74; P<0.001), whereas HCV was associated with a 2-fold probability of graft failure (odds ratio 1.97; 95% confidence interval 1.02-3.81; P=0.032).CONCLUSIONS:
The long-term outcome of OLT for ALC is comparable to that for HCV, even if graft survival is significantly better among ALC. These data support ALC as an excellent indication for OLT.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Fígado
/
Hepatite C
/
Alcoolismo
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Cirrose Hepática Alcoólica
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Gastroenterol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Itália