Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice.
Rev Esp Enferm Dig
; 101(7): 460-3, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19642836
ABSTRACT
OBJECTIVE:
melatonin has been demonstrated to have active antioxidant properties in different tissues during experimental cholestasis. The aim of this research was to study myocardial oxidative stress on obstructive jaundice, and to analyze the effect of melatonin on myocardial oxidative lesions. MATERIAL ANDMETHODS:
we achieved cholestasis by ligature and sectioning of the main bile duct. Melatonin was administered intraperitoneally (500 microg/kg/day). We measured malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) antioxidant enzyme levels in the heart tissue.RESULTS:
obstructive cholestasis increased MDA and decreased GSH as well as all antioxidant enzymes. Melatonin administration significantly decreased MDA values, and increased GSH and antioxidant enzymes on the icteric animal myocardium.CONCLUSIONS:
melatonin treatment prevents oxidative stress in the cardiac tissue as induced by experimental cholestasis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
/
Icterícia Obstrutiva
/
Melatonina
/
Miocárdio
/
Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
Rev Esp Enferm Dig
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Espanha