Upregulation of myostatin gene expression in streptozotocin-induced type 1 diabetes mice is attenuated by insulin.
Biochem Biophys Res Commun
; 388(1): 112-6, 2009 Oct 09.
Article
em En
| MEDLINE
| ID: mdl-19646957
ABSTRACT
Myostatin is a strong inhibitor of muscle growth, and its expression is increased in several types of muscle atrophy. However, whether or not myostatin expression is altered in muscle atrophy associated with type 1 diabetes (T1D) remains uncertain. In this study, we provided experimental evidence to show that myostatin mRNA increased in the early stage of T1D but came back to control levels later on. This expression pattern was closely correlated with the loss of body weight and atrogin-1 expression. Furthermore, induction of myostatin expression could be attenuated by insulin in T1D mice. Taken together, our findings indicate that the upregulation of myostatin expression most likely contributes to the muscle atrophy process during insulin deficiency.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atrofia Muscular
/
Regulação da Expressão Gênica
/
Diabetes Mellitus Experimental
/
Diabetes Mellitus Tipo 1
/
Miostatina
/
Insulina
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China