[Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
; 25(8): 699-701, 2009 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-19664392
ABSTRACT
AIM:
Killer cell immunoglobulin-like receptor (KIR) can modulate the activity of NK and T lymphocyte. To investigate whether the KIR genotype possessing a susceptibility to Graves disease (GD).METHODS:
Using PCR-SSP to detect KIR genotype in 96 GD patients and 96 randomly selected healthy controls.RESULTS:
The genotype frequency of 2DS2-, 2DL2-, 2DL3+, 2DL1+, 3DL1+, 3DS1-, 2DL5-, 2DS3-, 2DS5-, 2DS1-, 2DS4- was significantly higher in the patient group compared to that of the control group (6.25% vs 0%, P<0.05). Genotype of 2DS2-, 2DL2-, 2DL3+, 2DL1+, 3DL1+, 3DS1-, 2DL5-, 2DS3-, 2DS5-, 2DS1-, 2DS4+ is the most prevalent in the controls (28.13% vs 10.42%, P<0.01). Genotypes without activating KIR genes have higher frequency in patient group.CONCLUSION:
The difference of KIR genotypes between GD patients and healthy controls may explain the pathogenesis of GD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Graves
/
Receptores KIR
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China