Self-reactive gamma delta T cells are eliminated in the thymus.
Nature
; 343(6260): 714-9, 1990 Feb 22.
Article
em En
| MEDLINE
| ID: mdl-1968227
ABSTRACT
The genes encoding a gamma delta T-cell receptor specific for a major histocompatibility complex class I molecule encoded by the TIa locus have been inserted into the mouse germ line. In mice that do not express the TIa-encoded determinant, transgenic gamma delta T cells are a functional component of the CD4-CD8- 'double-negative' T cells in the thymus and peripheral lymphoid organs. In mice that express the TIa-encoded determinant, there are no transgenic gamma delta T cells in peripheral lymphoid organs, and there are no thymocytes expressing normal levels of the transgenic gamma delta T-cell receptor.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
Limite:
Animals
Idioma:
En
Revista:
Nature
Ano de publicação:
1990
Tipo de documento:
Article