MR imaging in Duchenne muscular dystrophy: quantification of T1-weighted signal, contrast uptake, and the effects of exercise.
J Magn Reson Imaging
; 30(5): 1130-8, 2009 Nov.
Article
em En
| MEDLINE
| ID: mdl-19856446
ABSTRACT
PURPOSE:
To quantify the differences between normal and corticosteroid-treated Duchenne muscular dystrophy (DMD) lower limb muscle using signal intensity measurements on T(1)-weighted and gadolinium contrast-enhanced images and by measurement of muscle T(2) values, and to investigate the effect of exercise. MATERIALS ANDMETHODS:
Eleven ambulant boys with DMD were imaged at 3 Tesla (T(1)-weighted, gadolinium enhancement and T(2) measurement) before stepping exercise and again (gadolinium, T(2) measurement) 4 days later and were compared with five healthy controls imaged 4 days before and after stepping exercise. Muscle region-of-interest signal intensities were referenced to external oil and gadolinium phantoms.RESULTS:
DMD thigh muscle T(2) values were significantly higher than normal values with the exception of the gracilis muscle. Eight of nine muscles studied showed a significant increase in T(1)-w signal intensity in DMD as compared to normal muscle, suggestive of increased fat infiltration in DMD muscle. In the DMD boys, an exercise effect (increased contrast enhancement) was only seen for the tibialis anterior muscle.CONCLUSION:
Referenced signal intensity measurements may be used to quantify differences between dystrophic and normal muscle without T(1) mapping. Stepping exercise does not have a large impact on subsequent MR imaging of dystrophic muscle.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Exercício Físico
/
Meios de Contraste
/
Distrofia Muscular de Duchenne
Tipo de estudo:
Diagnostic_studies
Limite:
Child
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Humans
/
Male
Idioma:
En
Revista:
J Magn Reson Imaging
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido