Supplementing iron and zinc: double blind, randomized evaluation of separate or combined delivery.
Eur J Clin Nutr
; 64(2): 153-60, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-19904293
ABSTRACT
BACKGROUND/OBJECTIVES:
Many children have diets deficient in both iron and zinc, but there has been some evidence of negative interactions when they are supplemented together. The optimal delivery approach would maximize clinical benefits of both nutrients. We studied the effectiveness of different iron and zinc supplement delivery approaches to improve diarrhea and anemia in a rural Bangladesh population. STUDYDESIGN:
Randomized, double blind, placebo-controlled factorial community trial.RESULTS:
Iron supplementation alone increased diarrhea, but adding zinc, separately or together, attenuated these harmful effects. Combined zinc and iron was as effective as iron alone for iron outcomes. All supplements were vomited <1% of the time, but combined iron and zinc were vomited significantly more than any of the other supplements. Children receiving zinc and iron (together or separately) had fewer hospitalizations. Separating delivery of iron and zinc may have some additional benefit in stunted children.CONCLUSIONS:
Separate and combined administration of iron and zinc are equally effective for reducing diarrhea, hospitalizations and improving iron outcomes. There may be some benefit in separate administration in stunted children.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zinco
/
Anemia Ferropriva
/
Suplementos Nutricionais
/
Deficiências Nutricionais
/
Transtornos do Crescimento
/
Ferro
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Eur J Clin Nutr
Assunto da revista:
CIENCIAS DA NUTRICAO
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos