The first scintigraphic detection of tumor necrosis factor-alpha in patients with complex regional pain syndrome type 1.
Anesth Analg
; 110(1): 211-5, 2010 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-19910617
ABSTRACT
Tumor necrosis factor (TNF)-alpha has been identified as a pathogenic factor in many immunologically based diseases and complex regional pain syndrome (CRPS). In this case series, we used radiolabeled technetium anti-TNF-alpha antibody to scintigraphically image TNF-alpha in 3 patients with type 1 CRPS. The results show that TNF-alpha was localized only in affected hands of patients with early-stage CRPS. No uptake was seen in clinically unaffected hands and late-stage CRPS. Our findings support the growing evidence for neuroimmune disturbance in patients with CRPS and may have important further implications for specific anticytokine treatment in patients with CRPS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Distrofia Simpática Reflexa
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Fator de Necrose Tumoral alfa
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Compostos Radiofarmacêuticos
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Anticorpos Monoclonais
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Anesth Analg
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha