A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors.

Holst, Birgitte; Nygaard, Rie; Valentin-Hansen, Louise; Bach, Anders; Engelstoft, Maja S; Petersen, Pia S; Frimurer, Thomas M; Schwartz, Thue W

Holst, Birgitte; Nygaard, Rie; Valentin-Hansen, Louise; Bach, Anders; Engelstoft, Maja S; Petersen, Pia S; Frimurer, Thomas M; Schwartz, Thue W.

Afiliação

Holst B; From the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, DK2200 Copenhagen, Denmark and. Electronic address: holst@sund.ku.dk.
Nygaard R; From the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, DK2200 Copenhagen, Denmark and; 7TM Pharma A/S, Fremtidsvej 3, DK5700 Hørsholm, Denmark.
Valentin-Hansen L; From the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, DK2200 Copenhagen, Denmark and.
Bach A; From the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, DK2200 Copenhagen, Denmark and.
Engelstoft MS; From the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, DK2200 Copenhagen, Denmark and.
Petersen PS; From the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, DK2200 Copenhagen, Denmark and.
Frimurer TM; 7TM Pharma A/S, Fremtidsvej 3, DK5700 Hørsholm, Denmark.
Schwartz TW; From the Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, DK2200 Copenhagen, Denmark and; 7TM Pharma A/S, Fremtidsvej 3, DK5700 Hørsholm, Denmark. Electronic address: tws@sund.ku.dk.

J Biol Chem ; 285(6): 3973-3985, 2010 Feb 05.

Article em En | MEDLINE | ID: mdl-19920139

Assuntos

Fenilalanina/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Triptofano/metabolismo; Regulação Alostérica; Sequência de Aminoácidos; Animais; Sítios de Ligação; Células COS; Chlorocebus aethiops; Humanos; Modelos Moleculares; Simulação de Dinâmica Molecular; Dados de Sequência Molecular; Mutação; Fenilalanina/química; Fenilalanina/genética; Ligação Proteica; Conformação Proteica; Receptores Adrenérgicos beta 2/genética; Receptores Adrenérgicos beta 2/metabolismo; Receptores Acoplados a Proteínas G/agonistas; Receptores Acoplados a Proteínas G/antagonistas & inibidores; Receptores Acoplados a Proteínas G/genética; Receptores de Grelina/genética; Receptores de Grelina/metabolismo; Retinaldeído/farmacologia; Rodopsina/agonistas; Rodopsina/química; Rodopsina/metabolismo; Triptofano/química; Triptofano/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenilalanina / Triptofano / Receptores Acoplados a Proteínas G Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2010 Tipo de documento: Article

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