Why proteins without an alpha-crystallin domain should not be included in the human small heat shock protein family HSPB.
Cell Stress Chaperones
; 15(4): 457-61, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-19921466
ABSTRACT
The presence of an alpha-crystallin domain documents the evolutionary relatedness of the ubiquitous family of small heat shock proteins. Sequence and three-dimensional structure provide no evidence for the presence of such a domain in HSPC034, recently proposed as the 11th member of the human HSPB family. Also, phylogenetic analyses detect no relationship between HSPC034 and the human HSPB1-10 sequences. Arguments are provided as to why inclusion in the HSPB family of proteins like HSPC034, which resemble small heat shock proteins in being heat-inducible and having chaperone-like properties and a low monomeric mass, but are evolutionarily unrelated, is misleading and confusing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Proteínas de Choque Térmico Pequenas
Limite:
Humans
Idioma:
En
Revista:
Cell Stress Chaperones
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Holanda