Osteonecrosis secondary to antiphospholipid syndrome: a case report, review of the literature, and treatment strategy.
Rheumatol Int
; 30(6): 719-23, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-20012628
ABSTRACT
Osteonecrosis is commonly present in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). Treatment of this condition remains extremely controversial. We present a treatment strategy of avascular necrosis of the knee in a patient with catastrophic antiphospholipid syndrome with a history of SLE and APS. Aggressive treatment with 12 rounds of plasmapheresis, intravenous immunoglobulin, rituximab, and cyclophosphamide led to the patient's recovery with no recurrence of symptoms during 16 months of follow up. In this report, we further discuss the pathogenesis of osteonecrosis and current understanding of the treatment of this disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteonecrose
/
Tíbia
/
Síndrome Antifosfolipídica
/
Fêmur
/
Joelho
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Rheumatol Int
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos