Axon extension occurs independently of centrosomal microtubule nucleation.
Science
; 327(5966): 704-7, 2010 Feb 05.
Article
em En
| MEDLINE
| ID: mdl-20056854
ABSTRACT
Microtubules are polymeric protein structures and components of the cytoskeleton. Their dynamic polymerization is important for diverse cellular functions. The centrosome is the classical site of microtubule nucleation and is thought to be essential for axon growth and neuronal differentiation--processes that require microtubule assembly. We found that the centrosome loses its function as a microtubule organizing center during development of rodent hippocampal neurons. Axons still extended and regenerated through acentrosomal microtubule nucleation, and axons continued to grow after laser ablation of the centrosome in early neuronal development. Thus, decentralized microtubule assembly enables axon extension and regeneration, and, after axon initiation, acentrosomal microtubule nucleation arranges the cytoskeleton, which is the source of the sophisticated morphology of neurons.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Centrossomo
/
Hipocampo
/
Microtúbulos
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha