[Antigenic composition and serologic characteristics of domestic acellular pertussis vaccine].
Zh Mikrobiol Epidemiol Immunobiol
; (6): 76-9, 2009.
Article
em Ru
| MEDLINE
| ID: mdl-20095429
ABSTRACT
AIM:
To assess antigenic composition consistency and serological characteristics of domestic acellular pertussis vaccine. MATERIALS ANDMETHODS:
Amount of pertussis toxin, filamentous hemagglutinin, agglutinogens types 1, 2, and 3 in experimental batches of vaccine was measured by enzyme immunoassay. Levels of antibodies to aforementioned antigens as well as to lipopolysaccbaride in serum samples obtained from patients with pertussis and healthy vaccinated children were measured by the same method. The amount of lypopolysaccharide was determined by LAL test.RESULTS:
Studied batches of vaccine were standard on amount of all protein antigens as well as lipopolysaccharide. Spectrum of antibodies to vaccine components in serum samples from patients with pertussis and healthy vaccinated children included antibodies to individual antigens pertussis toxin, filamentous hemagglutinin, lipopolysaccharide, agglutinogens types 1, 2, and 3.CONCLUSION:
Developed technology for manufacturing acellular pertussis vaccine allows to consistently produce preparations with standard amount of all components. Vaccine components interact with antibodies to wide spectrum of B. pertussis antigens.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bordetella pertussis
/
Coqueluche
/
Vacinas contra Difteria, Tétano e Coqueluche Acelular
/
Antígenos de Bactérias
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
Idioma:
Ru
Revista:
Zh Mikrobiol Epidemiol Immunobiol
Ano de publicação:
2009
Tipo de documento:
Article