Serum anti-endometrial antibodies in infertile women - potential risk factor for implantation failure.
Am J Reprod Immunol
; 63(5): 349-57, 2010 May.
Article
em En
| MEDLINE
| ID: mdl-20132165
ABSTRACT
PROBLEM:
Female infertility patients with diverse etiologies show increased production of autoantibodies. METHOD OF STUDY Immunoblot analysis of sera from patients with endometriosis and tubal factor infertility (TFI) and mass spectrometry identification of candidate antigens.RESULTS:
The immunoblot results demonstrated the presence of IgA and IgG anti-endometrial antibodies (AEA) to various antigens at molecular weights ranging from 10 to 200 kDa. Differences were detected in certain AEA reactions between the patients' groups and particular AEA were associated with in vitro fertilization (IVF) implantation failure. IgA AEA to a 47-kDa protein were more prevalent in TFI patients and were associated with unsuccessful IVF treatment. This antigen was subsequently identified as alpha-enolase.CONCLUSION:
Determination of the presence and spectra of AEA in patients with endometriosis and TFI undergoing IVF may be a useful marker to predict their pregnancy outcome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Implantação do Embrião
/
Autoanticorpos
/
Imunoglobulina A
/
Imunoglobulina G
/
Endométrio
/
Infertilidade Feminina
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Am J Reprod Immunol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estônia