[Surgical interventions in patients with myeloproliferative disease--prophylaxis and treatment of haemostatic disorders]. / Intervencní zákroky u jedincu s myeloproliferativními chorobami--prevence a e lécba poruch hemostázy.

ABSTRACT

Despite many decades of laboratory and clinical research of pathogenesis bleeding and thrombosis and the search for the identification of the risk factors, the accomplished results are unsatisfactory in clinical praxis. In our article, we discuss incidence, pathogenesis, clinical manifestation and the risk factors for coagulopathy in patients with myeloproliferative disease. The surgical procedures are associated with higher risk of morbidity and mortality. The aim of the article is the formulation of the recommendations concerning management of surgical interventions with the goal to reduce the risk of bleeding and thrombotic diathesis.