Polycomb group protein Ezh1 represses Nodal and maintains the left-right axis.
Dev Biol
; 341(2): 459-63, 2010 May 15.
Article
em En
| MEDLINE
| ID: mdl-20227405
ABSTRACT
The left-right (LR) axis is essential for the proper function of internal organs. In mammals and fish, left-sided Nodal expression governs LR patterning. Here, we show that the Polycomb group protein Ezh1, which is highly conserved from fish to human, participates in LR patterning. Knockdown of olezh1, a medaka homologue of Ezh1, led to LR reversal of internal organs. It was shown that OLEZH1 acts in silencing the expression of Spaw (a medaka homolog of Nodal) via a previously unknown pathway. Furthermore, coimmunoprecipitation showed physical interaction of Ezh1 with FoxH1, a Nodal regulator. This represents a novel mechanism for LR patterning and implies that Ezh1 has developmental importance.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Oryzias
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Padronização Corporal
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Proteínas de Peixes
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Proteína Nodal
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Dev Biol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Japão