ACTH protects against glucocorticoid-induced osteonecrosis of bone.
Proc Natl Acad Sci U S A
; 107(19): 8782-7, 2010 May 11.
Article
em En
| MEDLINE
| ID: mdl-20421485
ABSTRACT
We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteonecrose
/
Hormônio Adrenocorticotrópico
/
Substâncias Protetoras
/
Fêmur
/
Glucocorticoides
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos