Impact of nucleosome dynamics and histone modifications on cell proliferation during Arabidopsis development.
Heredity (Edinb)
; 105(1): 80-91, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20424644
ABSTRACT
Eukaryotic chromatin is a highly structured macromolecular complex of which DNA is wrapped around a histone-containing core. DNA can be methylated at specific C residues and each histone molecule can be covalently modified at a large variety of amino acids in both their tail and core domains. Furthermore, nucleosomes are not static entities and both their position and histone composition can also vary. As a consequence, chromatin behaves as a highly dynamic cellular component with a large combinatorial complexity beyond DNA sequence that conforms the epigenetic landscape. This has key consequences on various developmental processes such as root and flower development, gametophyte and embryo formation and response to the environment, among others. Recent evidence indicate that posttranslational modifications of histones also affect cell cycle progression and processes depending on a correct balance of proliferating cell populations, which in the context of a developing organisms includes cell cycle, stem cell dynamics and the exit from the cell cycle to endoreplication and cell differentiation. The impact of epigenetic modifications on these processes will be reviewed here.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Nucleossomos
/
Arabidopsis
/
Epigênese Genética
Idioma:
En
Revista:
Heredity (Edinb)
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Espanha