Total synthesis of (+/-)-marinopyrrole A and its library as potential antibiotic and anticancer agents.
J Comb Chem
; 12(4): 541-7, 2010 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-20429575
ABSTRACT
The first total synthesis of marine natural product, (+/-)-marinopyrrole A, has been accomplished via a nine-step synthesis in an overall yield of 30%. A small focused library based on marinopyrrole has been designed and synthesized. The scope of chemistry was investigated, and a robust chemistry suitable for library synthesis has been developed in the current study. The method that we have developed has made it possible to generate diverse analogues based on structurally novel marinopyrroles for study of potential antibiotic and anticancer activities.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirróis
Idioma:
En
Revista:
J Comb Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China