Regulation of gene expression in peripheral T cells by Runx transcription factors.
Adv Immunol
; 104: 1-23, 2009.
Article
em En
| MEDLINE
| ID: mdl-20457114
ABSTRACT
Members of the Runx family of transcription factors, Runx1-3, are essential regulators of the immune system a deficiency in one of the members, Runx1, results in complete ablation of hematopoiesis, and all three Runx proteins play important, nonredundant roles in immune system development and function. Here, we review gene regulation by Runx proteins in T lymphocytes, with a focus on their recently emerging roles in the development and function of peripheral CD4+ and CD8+ T lineages.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Regulação da Expressão Gênica
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Subunidades alfa de Fatores de Ligação ao Core
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Adv Immunol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos