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Impaired in vivo dopamine release in parkin knockout mice.
Oyama, Genko; Yoshimi, Kenji; Natori, Shihoko; Chikaoka, Yoko; Ren, Yong-Ri; Funayama, Manabu; Shimo, Yasushi; Takahashi, Ryosuke; Nakazato, Taizo; Kitazawa, Shigeru; Hattori, Nobutaka.
Afiliação
  • Oyama G; Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
Brain Res ; 1352: 214-22, 2010 Sep 17.
Article em En | MEDLINE | ID: mdl-20620130
parkin is the most frequent causative gene among familial Parkinson's disease (PD). Although parkin deficiency induces autosomal recessive juvenile parkinsonism (AR-JP, PARK2) in humans, parkin knockout (PKO) mice consistently show few signs of dopaminergic degeneration. We aimed to directly measure evoked extracellular dopamine (DA) overflow in the striatum with in vivo voltammetry. The amplitude of evoked DA overflow was low in PKO mice. The half-life time of evoked DA overflow was long in PKO mice suggesting lower release and uptake of dopamine. Facilitation of DA overflow by repetitive stimulation enhanced in the older PKO mice. Decreased dopamine release and uptake in young PKO mice suggest early pre-symptomatic changes in dopamine neurotransmission, while the enhanced facilitation in the older PKO mice may reflect a compensatory adaptation in dopamine function during the late pre-symptomatic phase of Parkinson's disease. Our results showed parkin deficiency may affect DA release in PKO mice, although it does not cause massive nigral degeneration or parkinsonian symptoms as in humans.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Corpo Estriado / Ubiquitina-Proteína Ligases Limite: Animals Idioma: En Revista: Brain Res Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Corpo Estriado / Ubiquitina-Proteína Ligases Limite: Animals Idioma: En Revista: Brain Res Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Japão