Immunodeficiency and renal impairment are risk factors for HIV-associated acute renal failure.
AIDS
; 24(14): 2239-44, 2010 Sep 10.
Article
em En
| MEDLINE
| ID: mdl-20634665
ABSTRACT
OBJECTIVE:
To identify risk factors for acute renal failure (ARF) in HIV-infected patients.DESIGN:
Observational cohort study of HIV-infected patients attending a South London HIV centre between January 1999 and December 2008.METHODS:
ARF was defined as a transient, more than 40% reduction in renal function as assessed by estimated glomerular filtration rate. Multivariate Poisson regression analysis was used to identify baseline and time-updated factors associated with ARF.RESULTS:
The incidence of ARF was 2.8 (95% confidence interval 2.41-3.24) episodes per 100 person-years. We observed a stepwise increase in ARF incidence with time accrued at lower CD4 cell count and at lower estimated glomerular filtration rate, with adjusted incidence rate ratios of 1 (reference), 1.56 (0.97-2.48), 2.08 (1.11-3.91), 6.38 (3.18-12.78) and 10.29 (5.11-20.98) for CD4 cell counts of more than 350, 201-350, 101-200, 51-100 and of 50/microl or less, and 1 (reference), 1.46 (0.86-2.51), 4.19 (2.37-7.42) and 27.00 (16.13-44.95) for estimated glomerular filtration rate more than 90, 75-89, 60-74 and less than 60 ml/min, respectively. Ethnicity, hepatitis B or C coinfection, exposure to combination antiretroviral therapy with or without indinavir, tenofovir or atazanavir and HIV viraemia were not associated with ARF.CONCLUSION:
Current levels of immunodeficiency and renal function were independent predictors of HIV-associated ARF.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Piridinas
/
Adenina
/
Infecções por HIV
/
Inibidores da Protease de HIV
/
Indinavir
/
Injúria Renal Aguda
/
Organofosfonatos
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido