In vitro affinity maturation of HuCAL antibodies: complementarity determining region exchange and RapMAT technology.
Immunotherapy
; 1(4): 571-83, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-20635988
ABSTRACT
Monoclonal antibodies gain ever-increasing importance in the treatment of human diseases across a broad range of indications. Diverse technologies currently exist, which are used to generate recombinant therapeutic antibodies that are basically indistinguishable from naturally occurring human immunoglobulins. We describe how human combinatorial antibody libraries are used together with unique optimization techniques to produce such therapeutically relevant proteins, for instance in the areas of oncology and inflammation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Recombinantes
/
Engenharia de Proteínas
/
Biblioteca de Peptídeos
/
Técnicas de Química Combinatória
/
Anticorpos Monoclonais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Immunotherapy
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
TERAPEUTICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha