Investigation of memory B cell responses to hepatitis B surface antigen in health care workers considered as non-responders to vaccination.
Vaccine
; 28(39): 6411-6, 2010 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-20682363
Up to 20% of health care workers are considered as non-responders to hepatitis B vaccination (anti-HBs<10 m UI/ml in serum). We have explored memory B cells differentiated in vitro into anti-HBs antibody-secreting cells (anti-HBs-SCs) by ELISPOT assay. Anti-HBs-SCs were detected in vaccinated responders (n = 11) and non-responders (n = 10) but IgG anti-HBs-SCs were significantly lower in the non-responder group (p<0.001). Low amounts of HBs antibodies were also quantified by ELISA in non-responders' sera. These results indicate that a suboptimal B cell response exists in non-responders to HBV vaccination. This B cell response may mediate a protection against clinically significant breakthrough hepatitis B infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Pessoal de Saúde
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Vacinas contra Hepatite B
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Anticorpos Anti-Hepatite B
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Antígenos de Superfície da Hepatite B
Limite:
Adult
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
França