Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells.
Leuk Res
; 35(2): 214-8, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-20691473
ABSTRACT
Triptolide is a compound isolated from the traditional Chinese medicinal herb Tripterygium wilfordii that shows potent anti-tumor activities, but its effects on acute myeloid leukemia with t(8;21) remain unclear. Here we report that triptolide inhibits cell proliferation and induces apoptosis in a dose- and time-dependent manner of t(8;21)-bearing Kasumi-1, SKNO-1 and CD34+ cells harvested from bone marrow samples of patients with t(8;21) leukemia. We show that triptolide triggers cleavage of the resultant AML1-ETO fusion protein of t(8;21), and causes downregulation of C-KIT followed by inhibition of JAK-STAT signaling. Triptolide downregulates p65 and inhibits the DNA-binding activity of NF-κB. Our data indicate that triptolide might be an effective agent for t(8;21) leukemia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenantrenos
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Cromossomos Humanos Par 8
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Cromossomos Humanos Par 21
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Leucemia Mieloide Aguda
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Transdução de Sinais
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Apoptose
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Antineoplásicos Alquilantes
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Proliferação de Células
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Diterpenos
Limite:
Humans
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China