Anti-SOX1 antibodies in patients with paraneoplastic and non-paraneoplastic neuropathy.
J Neuroimmunol
; 226(1-2): 177-80, 2010 Sep 14.
Article
em En
| MEDLINE
| ID: mdl-20701982
ABSTRACT
Anti-SOX1 antibodies have been described to be positive in patients with paraneoplastic Lambert-Eaton myasthenic syndrome and, in a lower amount, in patients with anti-Hu positive paraneoplastic neurological syndromes, and with SCLC alone, respectively. We found 5/32 patients with paraneoplastic neuropathy and, surprisingly, 4/22 patients with neuropathy of unknown origin positive for anti-SOX1 antibodies, whereas no patient with inflammatory neuropathy and no healthy controls showed any reactivity (p=0.007). All patients with neuropathy of unknown origin where followed up for four years without diagnosis of a tumour so far. Anti-SOX1 antibodies are associated with paraneoplastic neuropathies and may define another group of non-paraneoplastic, immune-mediated neuropathies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
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Síndrome Miastênica de Lambert-Eaton
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Polineuropatia Paraneoplásica
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Fatores de Transcrição SOXB1
Limite:
Aged
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Aged80
/
Animals
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha