Imaging of vascular inflammation with [11C]-PK11195 and positron emission tomography/computed tomography angiography.
J Am Coll Cardiol
; 56(8): 653-61, 2010 Aug 17.
Article
em En
| MEDLINE
| ID: mdl-20705222
ABSTRACT
OBJECTIVES:
We sought to investigate whether positron emission tomography/computed tomography (CT) angiography using [11C]-PK11195, a selective ligand for peripheral benzodiazepine receptors expressed in activated macrophages, can be used to image vascular inflammation.BACKGROUND:
Activated macrophages and T lymphocytes are fundamental elements in the pathogenesis of large-vessel vasculitides.METHODS:
Fifteen patients (age 52+/-16 years) with systemic inflammatory disorders (6 consecutive symptomatic patients with clinical suspicion of active vasculitis and 9 asymptomatic control patients) underwent positron emission tomography with [11C]-PK11195 and CT angiography. [11C]-PK11195 uptake was measured by calculating target-to-background ratios of activity normalized to venous blood.RESULTS:
Coregistration of positron emission tomography with contrast-enhanced CT angiography facilitated localization of [11C]-PK11195 arterial wall uptake. Visual analysis revealed focal [11C]-PK11195 uptake in the arterial wall of all 6 symptomatic patients, but in none of the asymptomatic controls. Although serum inflammatory biomarkers (C-reactive protein, erythrocyte sedimentation rate, white cell count) did not differ significantly between the 2 groups, symptomatic patients had increased [11C]-PK11195 vascular uptake (target-to-background ratio 2.41+/-1.59 vs. 0.98+/-0.10; p=0.001).CONCLUSIONS:
By binding to activated macrophages in the vessel wall, [11C]-PK11195 enables noninvasive imaging of vascular inflammation. Alternative longer-lived radioligands for probing peripheral benzodiazepine receptors are being tested for wider clinical applications.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasculite
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Radioisótopos de Carbono
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Angiografia
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Tomografia Computadorizada por Raios X
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Compostos Radiofarmacêuticos
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Tomografia por Emissão de Pósitrons
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Isoquinolinas
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Am Coll Cardiol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido