[Disposition of the potential antidepressive agent (3H) VUFB 15468 in mice and rats]. / Dispozice potenciálního antidepresíva (3H) VUFB 15468 u mysí a krys.
Cesk Farm
; 39(6): 258-60, 1990 Jul.
Article
em Cs
| MEDLINE
| ID: mdl-2078864
ABSTRACT
Excretion, biodistribution and pharmacokinetics of the above-mentioned drug after oral doses of 10 and 50 mg/kg were investigated. The drug is completely and rapidly resorbed from the digestive tract. It shows relatively large renal and metabolic clearance, it is extensively distributed in the tissues This results in its rapid elimination from plasma (t1/2 approximately 3 h) and, on the other hand, higher concentrations of radioactive drugs in tissues. Penetration and specific binding of VUFB 15468 in the murine brain in dependence on the administered dose were tested (ED50 approximately 4 mg/kg). Autoradiographic examination of the rat brain demonstrated an increased concentration of radioactive drugs in the cerebral cortex, hippocampus, hypophysis and central ganglia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzilaminas
Limite:
Animals
Idioma:
Cs
Revista:
Cesk Farm
Ano de publicação:
1990
Tipo de documento:
Article