Proteasome and oxidative phoshorylation changes may explain why aging is a risk factor for neurodegenerative disorders.
J Proteomics
; 73(11): 2230-8, 2010 Oct 10.
Article
em En
| MEDLINE
| ID: mdl-20813214
ABSTRACT
Neurodegenerative disorders (ND) belong to the most devastating diseases in the industrialized western world. Alzheimer disease (AD) is the most prevalent among these disorders followed by Parkinson disease (PD). Huntington disease (HD) is an autosomal dominantly inherited condition with a single mutation that causes disease in almost 100% of all cases. In this review we used previously published proteomics studies on AD, PD and HD to find cellular pathways changed similarly in ND and aging. All studies employed large gel two dimensional gel electrophoresis for protein separation and mass spectrometry for protein identification. Altered proteins were subjected to a KEGG pathway analysis and altered pathways determined for each disorder and aging. We found that besides the mitochondrial oxidative phosphorylation, the proteasome system are altered in aging and ND. The proteasome facilitates protein degradation which is commonly perturbed in ND which may link neurodegeneration to its largest risk factor-aging.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosforilação Oxidativa
/
Envelhecimento
/
Doenças Neurodegenerativas
/
Proteômica
/
Complexo de Endopeptidases do Proteassoma
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
J Proteomics
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha