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Pindolol potentiates the panicolytic effect of paroxetine in the elevated T-maze.
Sela, Vânia R; Roncon, Camila M; Zangrossi, Hélio; Graeff, Frederico G; Audi, Elisabeth A.
Afiliação
  • Sela VR; Department of Pharmacy and Pharmacology, State University of Maringá, Maringá, Pr, Brazil.
Life Sci ; 87(13-14): 445-50, 2010 Sep 25.
Article em En | MEDLINE | ID: mdl-20816996
AIMS: the ß-adrenergic and 5-HT(1A) receptor antagonist pindolol has been used in combination with antidepressant drugs, to shorten the time of onset of clinical efficacy and/or increase the proportion of responders in depressive and anxiety disorders. The aim of this study was to examine the interaction between pindolol and the selective serotonin reuptake inhibitor (SSRI), paroxetine in rats submitted to the elevated T-maze (ETM). MAIN METHODS: for assessing the drug combination effect, rats were administered with pindolol before paroxetine, using oral or intraperitoneal (i.p.) routes of acute administration, and were submitted to the ETM model. KEY FINDINGS: the highest dose of pindolol used (15.0mg/kg, i.p.) increased both inhibitory avoidance and escape latencies in the ETM, probably due to nonspecific motor deficit, since locomotion in a circular arena was also significantly decreased. The highest dose of paroxetine (3.0mg/kg, i.p.) selectively impaired escape, considered a panicolytic effect. Combination of pindolol (5.0mg/kg, i.p.) with an ineffective dose of paroxetine (1.5mg/kg, i.p.) impaired escape, indicating a potentiation of the panicolytic effect of paroxetine. By the oral route, neither paroxetine (3.0mg/kg) nor pindolol (5.0mg/kg) alone were effective, but the combination treatment had a marked panicolytic effect, again indicating drug potentiation. SIGNIFICANCE: the present results show that the combination of the ineffective doses of pindolol and paroxetine significantly increased escape latency, indicating a selective panicolytic effect. These findings give preclinical support for the use of this drug combination in the treatment of panic disorder (PD).
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos de Ansiedade / Pindolol / Transtorno de Pânico / Inibidores Seletivos de Recaptação de Serotonina / Paroxetina / Antagonistas Adrenérgicos beta / Antidepressivos de Segunda Geração Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos de Ansiedade / Pindolol / Transtorno de Pânico / Inibidores Seletivos de Recaptação de Serotonina / Paroxetina / Antagonistas Adrenérgicos beta / Antidepressivos de Segunda Geração Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2010 Tipo de documento: Article País de afiliação: Brasil