Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men.
Diabetes
; 60(1): 114-8, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-20876713
ABSTRACT
OBJECTIVE:
Animal studies indicate a prominent role of brain insulin signaling in the regulation of peripheral energy metabolism. We determined the effect of intranasal insulin, which directly targets the brain, on glucose metabolism and energy expenditure in humans. RESEARCH DESIGN ANDMETHODS:
In a double-blind, placebo-controlled, balanced within-subject comparison, 19 healthy normal-weight men (18-26 years old) were intranasally administered 160 IU human insulin after an overnight fast. Energy expenditure assessed via indirect calorimetry and blood concentrations of glucose, insulin, C-peptide, and free fatty acids (FFAs) were measured before and after insulin administration and the subsequent consumption of a high-calorie liquid meal of 900 kcal.RESULTS:
Intranasal insulin, compared with placebo, increased postprandial energy expenditure, i.e., diet-induced thermogenesis, and decreased postprandial concentrations of circulating insulin and C-peptide, whereas postprandial plasma glucose concentrations did not differ from placebo values. Intranasal insulin also induced a transient decrease in prandial serum FFA levels.CONCLUSIONS:
Enhancing brain insulin signaling by means of intranasal insulin administration enhances the acute thermoregulatory and glucoregulatory response to food intake, suggesting that central nervous insulin contributes to the control of whole-body energy homeostasis in humans.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Período Pós-Prandial
/
Termogênese
/
Metabolismo Energético
/
Insulina
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Humans
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Male
Idioma:
En
Revista:
Diabetes
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Alemanha